ea0044p157 | Neuroendocrinology and pituitary | SFEBES2016
Ibanez-Costa Alejandro
, Carmen Vazquez-Borrego Ma
, Fuentes-Fayos Antonio C.
, Venegas-Moreno Eva
, Galvez Ma Angeles
, Soto-Moreno Alfonso
, Kineman Rhonda D.
, Castano Justo P.
, Luque Raul M.
Pituitary adenomas (PA) comprise a commonly underestimated pathology in terms of incidence and associated morbi-mortality. Although somatostatin analogs and dopamine antagonists constitute the main medical treatments for PAs, an appreciable subset of patients are resistant or poorly responsive to these drugs and hence is crucial the search for new therapies. Biguanides such as metformin (MF; commonly used to treat type-2 diabetes), phenformin (PF) and buformin (BF) have been s...